Cambridge is a city located in the foothills of the Appalachian Mountains in beautiful southeastern Ohio in Guernsey County. Cambridge is at the crossroads of Ohio at Interstate 70 and 77, with driving distances - 80 miles east of Columbus, 122 south of Cleveland, 100 miles southwest of Pittsburgh and 50 miles west of Wheeling, West Virginia. The Interstate Highways share interchanges of U.S. Route 40 (East and West), which is now designated a National Scenic Byway, U.S. Route 22 (Northeast and Southwest) as well as State Route 209.